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Table 5 maspin expression in ovarian cancer

From: Role of maspin in cancer

Authors Years N. patients Maspin expression Clinical features/prognosis
Klasa-Mazurkiewicz et al. 2009 76 (ovarian cancer) 82.9% positive maspin Positive maspin = OS and PFS longer than maspin negative tumor.
   8(Krukemberg tumor) 87.2% positive maspin  
   10 (borderline) 90% borderline  
   42(benign tumor) 78.6% positive maspin  
   32(normal tissue) 53.1% positive maspin  
Moshira et al. 2005 46(ovarian cancer) 14(borderline) 65.9% positive maspin = 69% positive cytoplasm, 3.4% positive nucleus and 27.6% positive nucleus and cytoplasm  
   18(benign tumor) 57.1% positive maspin = 37.5% positive cytoplasm and 62.5% positive nucleus and cytoplasm  
    100% positive cytoplasm  
Sopel et al. 2010 132 (ovarian cancer) 88.6% positive maspin  
    22% positive nucleus Positive nuclear maspin = low tumor grade, less distant metastasis, low Figo stage, longer OS
    12.9% positive cytoplasm Positive cytoplasmic maspin = high tumor grade, probably distant metastasis, high Figo stage, shorter OS
Solomon et al. 2006 118 (serous ovarian cancer) 81.4% positive maspin  
    21.2% positive nucleus Positive nuclear maspin = lower VEGF and COX-2, OS:1803 days
    60.2% positive cytoplasm Positive cytoplasmic maspin = higher VEGF and COX-2, OS:637 days
    18.6% negative maspin Negative maspin = OS:1146 days
Bolat et al. 2008 60 (ovarian cancer) 88.3% positive cytoplasm Positive maspin = high VEGF, high grade, high clinical stage, ascite, lymphnode methastasis
    11.7% positive nucleus–cytoplasm  
Sood et al. 2002 80(ovarian cancer) 71% positive maspin Positive maspin = shorter OS, 63.3% high grade and 90% ascite
   10 (borderline) 26.6% positive nucleus Positive nuclear maspin = longer OS
   14 (benign tumor)   
Bauerschlag et al. 2010 87 (ovarian cancer) Not found Positive maspin = OS: 28 months and platinum-therapy resistance
     Negative maspin = OS: 57 months