Table 5 maspin expression in ovarian cancer
From: Role of maspin in cancer
Authors | Years | N. patients | Maspin expression | Clinical features/prognosis |
|---|---|---|---|---|
Klasa-Mazurkiewicz et al. | 2009 | 76 (ovarian cancer) | 82.9% positive maspin | Positive maspin = OS and PFS longer than maspin negative tumor. |
8(Krukemberg tumor) | 87.2% positive maspin | |||
10 (borderline) | 90% borderline | |||
42(benign tumor) | 78.6% positive maspin | |||
32(normal tissue) | 53.1% positive maspin | |||
Moshira et al. | 2005 | 46(ovarian cancer) 14(borderline) | 65.9% positive maspin = 69% positive cytoplasm, 3.4% positive nucleus and 27.6% positive nucleus and cytoplasm | |
18(benign tumor) | 57.1% positive maspin = 37.5% positive cytoplasm and 62.5% positive nucleus and cytoplasm | |||
100% positive cytoplasm | ||||
Sopel et al. | 2010 | 132 (ovarian cancer) | 88.6% positive maspin | |
22% positive nucleus | Positive nuclear maspin = low tumor grade, less distant metastasis, low Figo stage, longer OS | |||
12.9% positive cytoplasm | Positive cytoplasmic maspin = high tumor grade, probably distant metastasis, high Figo stage, shorter OS | |||
Solomon et al. | 2006 | 118 (serous ovarian cancer) | 81.4% positive maspin | |
21.2% positive nucleus | Positive nuclear maspin = lower VEGF and COX-2, OS:1803 days | |||
60.2% positive cytoplasm | Positive cytoplasmic maspin = higher VEGF and COX-2, OS:637 days | |||
18.6% negative maspin | Negative maspin = OS:1146 days | |||
Bolat et al. | 2008 | 60 (ovarian cancer) | 88.3% positive cytoplasm | Positive maspin = high VEGF, high grade, high clinical stage, ascite, lymphnode methastasis |
11.7% positive nucleus–cytoplasm | ||||
Sood et al. | 2002 | 80(ovarian cancer) | 71% positive maspin | Positive maspin = shorter OS, 63.3% high grade and 90% ascite |
10 (borderline) | 26.6% positive nucleus | Positive nuclear maspin = longer OS | ||
14 (benign tumor) | ||||
Bauerschlag et al. | 2010 | 87 (ovarian cancer) | Not found | Positive maspin = OS: 28 months and platinum-therapy resistance |
Negative maspin = OS: 57 months |