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Table 1 Maspin expression in breast cancer

From: Role of maspin in cancer

Authors Year N. patients Maspin expression Clinical pathological features/prognosis
Umekita et al. 2003 92 (invasive breast cancer) 18.5% positive maspin Positive maspin in invasive breast cancer and DCIS = large tumor size, presence of comedo-necrosis and high grade
   145 (Ductal Carcinoma In Situ) 9.6%positive maspin  
   27 (atypical hyperplasia) 3.7% positive maspin  
   94 (usual hyperplasia) 0%positive maspin  
Kim et al. 2003 192 (stage I-II breast cancer) 34.4% positive maspin Positive maspin in all type of invasive breast cancer = high grade
    36.4% positive maspin in invasive ductal carcinoma  
    7.1% positive maspin in invasive lobular carcinoma)  
Mohsin at al. 2003 1068 (breast cancer) 35% positive cytoplasm Positive cytoplasmic maspin = negative ER and PgR, high Mib, aneuploidy
    96% positive nucleus Positive nuclear maspin = positive ER and PgR
Umekita et al. 2002 168 (breast cancer) 27.4% positive maspin Positive maspin = 17.4% Large tumor size, 43.4% high grade, 65.2% negative ER and PgR, 43.4% positive p53 shorter PFS and OS
    72.6% negative maspin Negative maspin = 9% large tumor size, 19.6% high grade 35.2% negative ER and PgR 20,5% positive p53, better PFS and OS
Umekita et al. 2011 135 (triple negative breast cancer) 85.9% positive maspin Positive maspin = 43.1% age ≤ 50 years, 80.2% high grade
    14.1% negative maspin Negative maspin = 5.2% age ≤ 50 years, 42.1% high grade
Lee et al. 2006 80 (breast cancer) 31.3% positive maspin Positive maspin = 24% large tumor size, 52% high grade, 80% negative PgR, Short PFS and OS
    68.7% negative maspin Negative maspin = 7.2% large tumor size, 21.8% high grade, 41.8% negative PgR, better PFS and OS
Stark et al. 2012 16 (metastatic breast cancer) 30% positive maspin in primary tumor  
    13% positive maspin in brain metastasis  
Maass et al. 2001 45 (breast cancer) 64% positive maspin 17.7% of patients develop metastasis = 75% negative maspin
    36% negative maspin