Table 1 Summary of chemoresistance-related signaling pathways in this review
Transcription factor/signaling pathway | Tumor type | Drug resistance | References |
|---|---|---|---|
MYC | Hepatocellular Carcinoma, Leukemia, | Paclitaxel, Doxorubicin, | 18, 56, 64 |
AKT/PKB | Hepatocellular Carcinomaxx | Doxorubicin, 5-Fluorouracil | 68 |
WNT/β-Catenin | Hepatocellular Carcinoma, Neuroblastoma, Ovarian Cancer | Cisplatin, Doxorubicin, 5-Fluorouracil, Paclitaxel | 74, 75, 76, 77 |
Notch | Colon Cancer, Ovarian Cancer, Glioma | Oxaliplatin, Cisplatin, Temozolomide | 79, 80, 81, 82 |
Sonic hedgehog | Glioma, Gastric Cancer, Pancreatic Cancer, Ovarian Cancer, Prostate Cancer | Temozolomide, Oxaliplatin, Gemcitabine, Paclitaxel, Cisplatin | 82, 84, 85, 86, 87 |
NF-κB | Ovarian Cancer, Breast Cancer | Paclitaxel, Carboplatin, | 88, 89, 90 |