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Table 1 Antiplatelet medications and potential pharmacogenetic genes

From: Application of personalized medicine to chronic disease: a feasibility assessment

Drug name Brand name Potential pharmacogenetic genes PubMed ID Details
Acetylsalicylic acid Aspirin NTRK1; LTC4S; ITGB3 21390260; Risk of ADR and lower response-associated alleles
19862937;
12816731;
19390185
Clopidogrel Plavix CYP2C19; PON1; P2RY12; ABCB1; 22153531; Risk or phenotype-associated alleles. Any combination of two of CYP2C19 loss-of-function alleles is associated with diminished platelet response and worse cardiovascular outcomes
22088980;
22028352;
21881565;
21716271;
21497813;
21332306;
21170047;
20801498;
20126830;
19637098
Prasugrel* Effient None   Better suited for patients who cannot metabolize clopidogrel
Dipyridamoles-ASA Aggrenox    
  1. *Prasugrel is not on the Ontario or British Columbia public formularies, therefore economics were analyzed based on US pricing.