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Clinical and Translational Medicine

Table 4 Panels of markers for staging T.b. rhodesiense patients obtained through a combination of 3 molecules

From: New biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients

Panel

Markers

Cut-off

pAUC% (95% CI)*

SE% (95%CI)*

p value†

1

CXCL10 [ng/mL]

2.2

94 (89.9-97.3)

87.3 (78.9-94.4)

0.0001

 

CXCL13 [pg/mL]

23.3

  

0.01

 

MMP-9 [pg/mL]

499.8

  

0.01

2

CXCL10 [ng/mL]

2.2

94 (89.9-97.3)

87.3 (78.9-94.4)

0.0001

 

CXCL13 [pg/mL]

23.3

  

0.01

 

IgM [μg/mL]

17.8

  

0.02

  1. * pAUC and SE% were calculated for 100% SP.
  2. † Comparison between the pAUC (90-100% SP) of the panel and those of the markers individually considered obtained through the Bootstrap test for two correlated ROC curves.
  3. Both panels are positive when ≥2 molecules are above their cut-off.
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