Table 3 Ability of markers to classify T.b. rhodesiense patients according to the presence of parasites in CSF
From: New biomarkers for stage determination in Trypanosoma brucei rhodesiense sleeping sickness patients
Marker | p value* | AUC% (95% CI) | Cut-off | SP% (95% CI) | SE% (95% CI) |
|---|---|---|---|---|---|
IgM [μg/mL] | < 0.0001 | 84.5 (73.9-95.2) | 17.8 | 85.7 (66.7-100) | 81.3 (71.9-90.6) |
MMP-9 [pg/mL] | < 0.0001 | 85.2 (74.3-96) | 499.8 | 90.5 (76.2-100) | 76.6 (65.6-85.9) |
CXCL13 [pg/mL] | < 0.0001 | 80.4 (69.1-91.8) | 200.3 | 90.5 (76.2-100) | 73.4 (62.5-84.4) |
VCAM-1 [ng/mL] | < 0.0001 | 83.2 (73.7-92.7) | 43.9 | 76.2 (57.1-90.5) | 78.1 (67.2-87.5) |
B2MG [ng/mL] | < 0.0001 | 82.0 (71.3-92.7) | 1462 | 66.7 (47.6-85.7) | 85.9 (76.6-93.8) |
ICAM-1 [ng/mL] | < 0.0001 | 83.3 (73–93.6) | 4.7 | 81.0 (61.9-95.2) | 73.4 (62.5-84.4) |
Neopterin [nmol/L] | < 0.0001 | 75.5 (63.9-87.1) | 69.4 | 81.0 (61.9-95.2) | 65.6 (54.7-76.6) |
CXCL10 [ng/mL] | 0.002 | 73.1 (59.3-86.8) | 7.5 | 47.6 (28.6-66.7) | 92.2 (84.4-98.4) |
WBC (Cells/μL) | < 0.0001 | 87.4 (77.4-97.4) | 6.5 | 71.4 (52.4-90.5) | 95.3 (89.1-100) |