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Table 2 Malignant networks also are partly activated by oxaliplatin treatment, indicating an inherent competition between efficacy and toxicity which can be characterized based on high throughput analysis

From: Network insights on oxaliplatin anti-cancer mechanisms

Overview of some signaling changes upon oxaliplatin treatment
Signaling network Molecules in dataset # Up regulated # Down regulated
Ovarian Cancer 64 34 30
Glioma Signaling 50 26 24
Prostate Cancer 53 31 22
Non-Small Cell Lung Cancer 39 25 14
Colorectal Cancer Metastasis 116 59 57
Basal Cell Carcinoma 25 13 12
Melanoma 25 14 11
Small Cell Lung Cancer 47 28 19
VEGF 49 25 24
Renal Cell Carcinoma 45 30 15
Sonic Hedgehog 15 7 8
Pancreatic Adenocarcinoma 65 37 28