Table 1 Important pathogenic features of nontypeable Haemophilus influenzae
From: Haemophilus influenzae and the lung (Haemophilus and the lung)
Mucociliary interactions | Binding to mucus |
| Â | Inhibition of ciliary function/death of ciliary cells |
Attachment to respiratory mucosa | Adhesins |
| Â | Pili |
| Â | Hia/Hap proteins |
Evasion of mucosal immunity | IgA proteases |
| Â | Microcolony formation |
| Â | Phase variation/antigenic drift |
Intracellular survival/invasion of local tissue | Survival inside mononuclear phagocytes and epithelial cells |
| Â | Extensive invasion of lung parenchyma |