Table 1 Important pathogenic features of nontypeable Haemophilus influenzae
From: Haemophilus influenzae and the lung (Haemophilus and the lung)
| Mucociliary interactions | Binding to mucus |
| Inhibition of ciliary function/death of ciliary cells | |
| Attachment to respiratory mucosa | Adhesins |
| Pili | |
| Hia/Hap proteins | |
| Evasion of mucosal immunity | IgA proteases |
| Microcolony formation | |
| Phase variation/antigenic drift | |
| Intracellular survival/invasion of local tissue | Survival inside mononuclear phagocytes and epithelial cells |
| Extensive invasion of lung parenchyma |