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  1. Review

    Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis

    Extensive genomic and transcriptomic heterogeneity in human cancer often negatively impacts treatment efficacy and survival, thus posing a significant ongoing challenge for modern treatment regimens. State-of-...

    Darrell L. Ellsworth, Heather L. Blackburn, Craig D. Shriver, Shahrooz Rabizadeh, Patrick Soon-Shiong and Rachel E. Ellsworth

    Clinical and Translational Medicine 2017 6:15

    Published on: 12 April 2017

  2. Perspective

    Translational research in pediatric pulmonary disease, 2017

    As readers of this journal know, translational research is the application of basic science findings to improve clinical care; a process that was once called “bench-to-bedside” research. In my field of pediatr...

    Bruce K. Rubin

    Clinical and Translational Medicine 2017 6:12

    Published on: 1 March 2017

  3. Review

    Single cell sequencing: a distinct new field

    Single cell sequencing (SCS) has become a new approach to study biological heterogeneity. The advancement in technologies for single cell isolation, amplification of genome/transcriptome and next-generation se...

    Jian Wang and Yuanlin Song

    Clinical and Translational Medicine 2017 6:10

    Published on: 20 February 2017

  4. Commentary

    Integrating phosphoproteomics into the clinical management of prostate cancer

    Phosphoproteomic analysis of tumor samples has the potential to uncover significant insights into kinase signaling networks present in late stage prostate cancer that are complementary to genomic and transcrip...

    Larry C. Cheng, Victor M. Tan, Shridar Ganesan and Justin M. Drake

    Clinical and Translational Medicine 2017 6:9

    Published on: 14 February 2017

  5. Commentary

    Tissue is the issue and tissue competition. Re-biopsy for mutation T790: where and why?

    Lung cancer is still the leading cause of death among all cancers. During the last 15 years, pharmacogenomics of lung cancer have established targeted therapy with tyrosine kinase inhibitors (TKIs) for epiderm...

    Paul Zarogoulidis, Mina Gaga, Haidong Huang, Kaid Darwiche, Aggeliki Rapti and Wolfgang Hohenforst-Schmidt

    Clinical and Translational Medicine 2017 6:6

    Published on: 18 January 2017

  6. Research

    The antineoplastic drug, trastuzumab, dysregulates metabolism in iPSC-derived cardiomyocytes

    The targeted ERBB2 therapy, trastuzumab, has had a tremendous impact on management of patients with HER2+ breast cancer, leading to development and increased use of further HER2 targeted therapies. The major c...

    Brian M. Necela, Bianca C. Axenfeld, Daniel J. Serie, Jennifer M. Kachergus, Edith A. Perez, E. Aubrey Thompson and Nadine Norton

    Clinical and Translational Medicine 2017 6:5

    Published on: 18 January 2017

  7. Perspective

    A systematic approach to cancer: evolution beyond selection

    Cancer is typically scrutinized as a pathological process characterized by chromosomal aberrations and clonal expansion subject to stochastic Darwinian selection within adaptive cellular ecosystems. Cognition ...

    William B. Miller and John S. Torday

    Clinical and Translational Medicine 2017 6:2

    Published on: 3 January 2017

  8. Research

    MRI detection of endothelial cell inflammation using targeted superparamagnetic particles of iron oxide (SPIO)

    There is currently no clinical imaging technique available to assess the degree of inflammation associated with atherosclerotic plaques. This study aims to develop targeted superparamagnetic particles of iron ...

    Joyce M. S. Chan, Maggie S. H. Cheung, Richard G. J. Gibbs and Kishore K. Bhakoo

    Clinical and Translational Medicine 2017 6:1

    Published on: 2 January 2017

  9. Research

    Novel paradigm for immunotherapy of ovarian cancer by engaging prophylactic immunity against hepatitis B virus

    Only eight women out of one hundred diagnosed with ovarian epithelial cancers, which progressed to the clinical stage IV, survive 10 years. First line therapies: surgery, chemotherapy, and radiation therapy in...

    Marek Malecki, Emily Putzer, Caroline Quach, Chaitanya Dodivenaka and Xenia Tombokan

    Clinical and Translational Medicine 2016 5:44

    Published on: 30 November 2016

  10. Review

    Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation

    The major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it o...

    Geeta Shroff, Dipin Thakur, Varun Dhingra, Deepak Singh Baroli, Deepanshu Khatri and Rahul Dev Gautam

    Clinical and Translational Medicine 2016 5:41

    Published on: 20 October 2016

  11. Research

    Clinical study of Gene-Eden-VIR/Novirin in genital herpes: suppressive treatment safely decreases the duration of outbreaks in both severe and mild cases

    We conducted a clinical study that tested the effect of suppressive treatment with the botanical product Gene-Eden-VIR/Novirin on genital herpes. Our previous paper showed that the treatment decreased the numb...

    Hanan Polansky, Edan Itzkovitz and Adrian Javaherian

    Clinical and Translational Medicine 2016 5:40

    Published on: 20 October 2016

  12. Research

    Serum levels of S100A6 are unaltered in patients with resectable cholangiocarcinoma

    Elevated expression levels of S100A6, a calcium-binding low-molecular-weight protein, were demonstrated in various malignancies. Moreover, increased serum levels of S100A6 were suggested as a novel biomarker f...

    Sven H. Loosen, Fabian Benz, Jennifer Niedeggen, Maximilian Schmeding, Florian Schüller, Alexander Koch, Mihael Vucur, Frank Tacke, Christian Trautwein, Christoph Roderburg, Ulf P. Neumann and Tom Luedde

    Clinical and Translational Medicine 2016 5:39

    Published on: 27 September 2016

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