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Clinical and Translational Medicine
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Clinical and translational cardiovascular medicine

Section edited by: Yong-Xiao Wang

The primary objective of this section is to promote significant enhancements in etiology, mechanistic understanding, prevention, diagnosis, and therapies of cardiovascular diseases. This section covers epidemiological investigations, clinical trials or observational studies, novel technologies or instruments, human biology, cell or animal models, mechanism investigations, genomics, biomarkers, bioengineering, bioinformatics, drug discovery and development, gene therapies, drug and gene deliveries, biomaterial utilization, and healthcare regulation or policy of all cardiovascular diseases, including but not limited to, heart attack, cardiac arrhythmias, heart failure, heart valve disease, congenital heart disease, heart muscle disease (cardiomyopathy), stroke, hypertension, coronary artery disease, atherosclerosis, pulmonary hypertension, and aneurysm.

  1. The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9)–inhibiting drugs have provided an effective, but extremely expensive treatment for the management of low density lipoprotein (LDL). Our aim w...

    Authors: Xinyang Li, Meiniang Wang, Xinhua Zhang, Chuxin Liu, Haitao Xiang, Mi Huang, Yingying Ma, Xiaoyan Gao, Lin Jiang, Xiaopan Liu, Bo Li, Yong Hou, Xiuqing Zhang, Shuang Yang and Naibo Yang
    Citation: Clinical and Translational Medicine 2020 9:16
    Content type: Research Published on:

  2. Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate important intracellular signalling and vesicle trafficking events via the generation of 3-phosphoinositides. Comprising eight core isoforms ac...

    Authors: Tom N. Durrant and Ingeborg Hers
    Citation: Clinical and Translational Medicine 2020 9:8
    Content type: Review Published on:

  3. Considering the important role of microbiome, many of current investigations have focused on its beneficial aspects. Although, research explores new dimensions of the impact of microbiome and examines the diff...

    Authors: Ava Behrouzi, Amir Hossein Nafari and Seyed Davar Siadat
    Citation: Clinical and Translational Medicine 2019 8:16
    Content type: Review Published on:

  4. Pulmonary endothelial cells’ (ECs) injury and apoptotic death are necessary and sufficient for the pathogenesis of the acute respiratory distress syndrome (ARDS), regardless of epithelial damage. Interaction o...

    Authors: Trushil Shah, Shanshan Qin, Mona Vashi, Dan N. Predescu, Niranjan Jeganathan, Cristina Bardita, Balaji Ganesh, Salvatore diBartolo, Louis F. Fogg, Robert A. Balk and Sanda A. Predescu
    Citation: Clinical and Translational Medicine 2018 7:19
    Content type: Research Published on:

  5. Human Yippee-like-4 (YPEL4) is a member of the YPEL gene family. This family has been characterized as the first highly conserved family of genes coding for proteins that contain putative zinc-finger-like meta...

    Authors: Lillian Truong, Yun-Min Zheng, Tengyao Song, Yi Tang and Yong-Xiao Wang
    Citation: Clinical and Translational Medicine 2018 7:16
    Content type: Review Published on:

  6. Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin resistance. Lately, adipose tissue has gained prominence as an effector site of fetuin-A. Although fetuin-A—induced proinflammator...

    Authors: Saori Maruo, Katsuhito Mori, Koka Motoyama, Miyuki Nakamura, Reina Kawarabayashi, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Tetsuo Shoji, Masaaki Inaba and Masanori Emoto
    Citation: Clinical and Translational Medicine 2018 7:9
    Content type: Research Published on:

  7. Recently, non-vitamin K antagonist oral anticoagulants such as direct thrombin and direct factor Xa inhibitors have been prescribed for prevention of embolic stroke. While in Japan, argatroban, also a direct t...

    Authors: Taizen Nakase, Junta Moroi and Tatsuya Ishikawa
    Citation: Clinical and Translational Medicine 2018 7:2
    Content type: Research Published on:

  8. Mitochondria play a key role in the homeostasis of the vast majority of the body’s cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obst...

    Authors: James D. McCully, Sidney Levitsky, Pedro J. del Nido and Douglas B. Cowan
    Citation: Clinical and Translational Medicine 2016 5:16
    Content type: Review Published on: